How does Tabex work?
Rated No.1 By Smoking Cessation Programs Los Angeles 2016
Tabex® has a comprehensive effect on pathogenetic mechanisms of nicotine dependence:
- The alkaloid cytisine is a powerful antagonist of nicotine receptors.
- Cytisine has wider therapeutic range than nicotine which makes its profile of action safer.
- Cytisine reduces depressive symptoms related to discontinuation of nicotine intoxication
- Compared to nicotine, it has much weaker effect on the peripheral nervous system and blood pressure
Chemical characteristics and content of Tabex
Each tablet contains 0.0015 g cytisine
Empirical formula of cytisine: C11H14ON2
Ensuing from the molecular orbital calculations after Kier(1969), it is evident that the molecular configurations of nicotine and acetylcholine have a quaternary nitrogen atom which is with a negative charge and located at 4.85 +/- 0.1 A, considered to be responsible for the nicotine-like activity. In cytisine the nitrogen atom in ring C appears at 4.8-9 A from the oxygen atom of the pyridine group and is also negatively charged.
The prolonged clinical and toxicological studies in many countries all over the world have proved the enormous harm of smoking on all organs and systems of the human organism. The danger of cardiovascular incidents (myocardial infarction, stenocardia, peripheral vascular diseases), diseases of the respiratory system (lung cancer, tracheobronchitis, etc.), as well as psychic and physiological dependence of addictive type is mostly emphasized.
Fig. 2 Stereoisomeric formulae of cytisine and nicotine (after Barlow, R.B. and McLeod, L.J.)
The treatment of nicotine addiction is a complex process in which drug therapy occupies an important part. Sopharma produces the drug Tabex, developed on the basis of the alkaloid Cytisine, which has an action similar to that of nicotine.
Pharmacodynamics of Cytisine
Cytisine is an agonist of the cholinoreceptors in the vegetative ganglia and belongs to the group of the gangliostimulating drugs. It excites the nicotine-sensitive cholinoreceptors of the postsynaptic membranes in the vegetative ganglia, chromaffin cells in the molecular part of the suprarenal gland and sinocarotid reflexogenic zone, which results in excitation of the respiratory center, predominantly through the reflexes, simulation of adrenaline release by the medullar part of the suprarenal glands and a rise in the blood pressure. After its absorption in the gastrointestinal tract, cytisine plays the part of a nicotine-substitute substance which decreases the period of interaction between nicotine and the corresponding receptors. This in turn leads to a gradual decrease and interruption of the smokers' psychic and physical nicotine dependence.
Many researchers confirm in different pharmacological experiments the similarity between the pharmacological properties of cytisine and nicotine, as described by Dale & Laidlaw (1912) and confirmed also by the conclusions of Zachowsky (1937), Anichkov (1937), Dobrev and Paskov (1953), Daleva (1963), etc., in whose opinion cytisine is more potent as a gangliostimulating than as a ganglioblocking agent.
Fig. 3 Mechanism of action of cytisine. Creation of the vicious cycle of tobacco addiction and the way to exit from it by means of Tabex
This similarity between the peripheral effects of cytisine and nicotine is more quantitative than qualitative. Comparable effects of both drugs have been obtained in experiments on cats and rats (studies on the blood pressure), or on guinea-pig ileum and rat diaphragm, the doses of cytisine being 1/4 to 2/3 from the nicotine dose.
As regards the effects on the central nervous system, Cytisine has a weaker effect on the respiration of anesthetized rabbits, compared to the effects on the peripheral nervous system.
Tabex is probably the most safest anti smoking product on the world market. Buy Tabex from us only for the genuine brand. Be aware of counterfeits. We ship Tabex to Australia daily. All orders posted from our UK office.