TABEX® is an original Bulgarian supplement with over 40 years of research
Tabex is not a medicine or neither a prescription medication and is merely a supplement made of plant extract.
No products advertised are intended to treat, cure or prevent any disease.
In the distant 1865 acad. А. Orehov found out and chemically analysed the alkaloid cytisine contained in Family Papilionaceae and is the main active substance of TABEX®. Cytisine belongs to the group of nicotine blockers that are known in clinical practice as respiration stimulators. The pharmacological study of cytisine at the Pharmacology Department of the Sofia Medical Institute started as early as in the 50s of the last century and their aim was to create an ampoule dosage form for the needs of resuscitation. During experimental studies on anaesthetised cats, two famous Bulgarian pharmacologists – Prof. Paskov and Dr. Dobrev reached to the important conclusion that due to its lower toxicity than nicotine and mostly to its weaker peripheral effect on the cardiovascular system.
The intriguing thing in that story is that half a century ago two heavy smokers-pharmacologists arrived at the good idea how to give an opportunity to the cigarettes-dependent individuals to go through the abstinence syndrome easily (a condition of bad mood, anxiety, headache, etc.), accompanying the cigarette quitting period and at the same time to feel stimulated.
In 1962 in Bulgaria Prof. Isaev isolated cytisine from the golden chain plant and started an intensive research on the creation of the original supplement TABEX®. Large clinical trials in Bulgaria, Germany and Poland followed that confirmed the efficacy of the supplement.
It is well known that depressive moods and abstinence syndrome are psychic conditions, that accompany any dependency, that are most difficult to overcome. The extensive clinical research conducted in Bulgaria and abroad confirmed this advantage of TABEX® – trademark of Sopharma.
Names and Dates
Hussman and Marme (1863) isolated cytisine – white crystalline powder with bitter taste
Dale and Laidlow (1912) discovered the pharmacological resemblance between nicotine and cytisine
Zachowski (1937) confirmed the above results discovered
Mashkovski (1938) worked on the creation of a respiratory cytisine-containing analeptic
Isaev (1962) isolated and standardized cytisine out of Cytisus laburnum.
Daleva and Sheykova (1963) conducted pharmacological studies on cytisine.
The technology for Tabex ® manufacture was developed during the period 1962-1964. In September 1964 the first batch of 3685 Tabex packages was manufactured.